Ovarian cancer is one of the most lethal malignancies and often presents at an advanced stage, resulting in a poor prognostic outlook. Platinum chemotherapy leads to an initial clinical response, however most patients will ultimately relapse and there remains a sub-group who are intrinsically resistant to platinum. I focussed on high grade serous ovarian cancer (HGSOC), the most common subtype.
Salinomycin as a potential chemotherapeutic compound in cisplatin-resistant ovarian cancer: effects and mechanisms. 2013, PhD Thesis, University of Basel, Faculty of Science. Ballesteros-Meja, L.. Examining and addressing the Wallacean shortfall: species distribution modelling and biodiversity patterns of hawkmoths in the old world. 2013, PhD Thesis, University of Basel, Faculty of Science.
Ovarian cancer. Ovarian cancer is when abnormal cells in the ovary begin to grow and divide in an uncontrolled way, and eventually form a growth (tumour). Find out what it is, how you’re diagnosed, about treatment and side effects, and where to get practical and emotional support. What is ovarian cancer? Symptoms of ovarian cancer. Symptoms can include feeling full quickly, bloating, an.
Prospective Study of Symptoms of Ovarian Cancer in Postmenopausal Women Penny Louise Allen A thesis submitted for the degree of Doctor of Philosophy at University College London Department of Gynaecological Oncology Institute for Women’s Health 2010. 2 Declaration I, Penny Louise Allen, confirm that the work presented in this thesis is my own. Where information has been derived from other.
The calpain system is associated with cancer chemotherapeutic response in both in vivo and in vitro studies. Previous immunohistochemistry (IHC) data conducted in our group indicated that high calpain-2 expression was associated with both the resistance to platinum-based adjuvant chemotherapy and worse patient outcome; moreover calpain-2 appeared as an independent prognostic factor in.
This PhD aimed to address these challenges by firstly exploring the potential role of sapacitabine, a novel oral nucleoside analogue, for the treatment of ovarian cancer alongside the poly (ADP-ribose) polymerase (PARP) inhibitor rucaparib and platinum. Homologous recombination DNA repair functional status has been explored as a biomarker for their stratified use. Additionally, this project.
The dysregulation of DNA damage repair has a significant clinical impact in ovarian cancer. DNA double strand breaks (DSB) are repaired by the homologous recombination (HR) and the non homologous end joining (NHEJ) pathways. 50 % of ovarian cancers are HR defective (HRD), which makes these cancers sensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). The role of PARP-1 in NHEJ, and the.
Vascular endothelial growth factor C (VEGFC) promotes tumor progression in several tumor types, mainly through the stimulation of lymphangiogenesis and lymphatic metastasis. The expression and biological significance of the VEGFCNEGFR3 pathway in ovarian cancer growth and dissemination has been investigated in this thesis using ovarian carcinoma cell lines and tumor animal models.