Ovarian Cancer Doctorate. - PhD-Dissertations.com.

Phd Thesis On Ovarian Cancer

Ovarian cancer is the deadliest gynaecological cancer, with less than half of patients surviving five years from diagnosis. The asymptomatic nature of the early disease commonly results in diagnosis at an advanced stage where peritoneal metastases are prevalent, and the disease rapidly develops resistance to platinum-based agents. Innovative treatments are needed to combat this untreatable.

Phd Thesis On Ovarian Cancer

Ovarian cancer (OC) accounts for 4% of all cancer cases and 4.2% of all cancer deaths worldwide. OC is the most lethal gynecological cancer because it lacks early disease symptoms and does not have a specific diagnostic marker. As a result, more than 70% of OC patients are diagnosed in later stages when the disease has already metastasized and the 5-year survival rate has decreased to less.

Phd Thesis On Ovarian Cancer

Abstract. Ovarian cancer arises almost exclusively in epithelial cells derived from the surface of the ovary. It is thought that the continual damage caused by ovulation (break of.

Phd Thesis On Ovarian Cancer

Ovarian cancer is one of the most lethal malignancies and often presents at an advanced stage, resulting in a poor prognostic outlook. Platinum chemotherapy leads to an initial clinical response, however most patients will ultimately relapse and there remains a sub-group who are intrinsically resistant to platinum. I focussed on high grade serous ovarian cancer (HGSOC), the most common subtype.

Phd Thesis On Ovarian Cancer

Salinomycin as a potential chemotherapeutic compound in cisplatin-resistant ovarian cancer: effects and mechanisms. 2013, PhD Thesis, University of Basel, Faculty of Science. Ballesteros-Meja, L.. Examining and addressing the Wallacean shortfall: species distribution modelling and biodiversity patterns of hawkmoths in the old world. 2013, PhD Thesis, University of Basel, Faculty of Science.

Phd Thesis On Ovarian Cancer

Ovarian cancer. Ovarian cancer is when abnormal cells in the ovary begin to grow and divide in an uncontrolled way, and eventually form a growth (tumour). Find out what it is, how you’re diagnosed, about treatment and side effects, and where to get practical and emotional support. What is ovarian cancer? Symptoms of ovarian cancer. Symptoms can include feeling full quickly, bloating, an.

Phd Thesis On Ovarian Cancer

Prospective Study of Symptoms of Ovarian Cancer in Postmenopausal Women Penny Louise Allen A thesis submitted for the degree of Doctor of Philosophy at University College London Department of Gynaecological Oncology Institute for Women’s Health 2010. 2 Declaration I, Penny Louise Allen, confirm that the work presented in this thesis is my own. Where information has been derived from other.

Phd Thesis On Ovarian Cancer

The calpain system is associated with cancer chemotherapeutic response in both in vivo and in vitro studies. Previous immunohistochemistry (IHC) data conducted in our group indicated that high calpain-2 expression was associated with both the resistance to platinum-based adjuvant chemotherapy and worse patient outcome; moreover calpain-2 appeared as an independent prognostic factor in.

Phd Thesis On Ovarian Cancer

This PhD aimed to address these challenges by firstly exploring the potential role of sapacitabine, a novel oral nucleoside analogue, for the treatment of ovarian cancer alongside the poly (ADP-ribose) polymerase (PARP) inhibitor rucaparib and platinum. Homologous recombination DNA repair functional status has been explored as a biomarker for their stratified use. Additionally, this project.

Phd Thesis On Ovarian Cancer

The dysregulation of DNA damage repair has a significant clinical impact in ovarian cancer. DNA double strand breaks (DSB) are repaired by the homologous recombination (HR) and the non homologous end joining (NHEJ) pathways. 50 % of ovarian cancers are HR defective (HRD), which makes these cancers sensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). The role of PARP-1 in NHEJ, and the.

Phd Thesis On Ovarian Cancer

Vascular endothelial growth factor C (VEGFC) promotes tumor progression in several tumor types, mainly through the stimulation of lymphangiogenesis and lymphatic metastasis. The expression and biological significance of the VEGFCNEGFR3 pathway in ovarian cancer growth and dissemination has been investigated in this thesis using ovarian carcinoma cell lines and tumor animal models.

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